Protein Details: Transient receptor potential cation channel subfamily V member 4

Protein ID

ICDB_Pro_1474

Protein Name

Transient receptor potential cation channel subfamily V member 4

Gene Name

Trpv4; Trp12; Vrl2; Vroac

Organism

Mus musculus (Mouse)

Length

871 amino acids

AlphaFoldDB

AF-Q9EPK8-F1-model_v4.pdb

Function

Sequence

MADPGDGPRAAPGEVAEPPGDESGTSGGEAFPLSSLANLFEGEEGSSSLSPVDASRPAGPGDGRPNLRMKFQGAFRKGVPNPIDLLESTLYESSVVPGPKKAPMDSLFDYGTYRHHPSDNKRWRRKVVEKQPQSPKAPAPQPPPILKVFNRPILFDIVSRGSTADLDGLLSFLLTHKKRLTDEEFREPSTGKTCLPKALLNLSNGRNDTIPVLLDIAERTGNMREFINSPFRDIYYRGQTSLHIAIERRCKHYVELLVAQGADVHAQARGRFFQPKDEGGYFYFGELPLSLAACTNQPHIVNYLTENPHKKADMRRQDSRGNTVLHALVAIADNTRENTKFVTKMYDLLLLKCSRLFPDSNLETVLNNDGLSPLMMAAKTGKIGVFQHIIRREVTDEDTRHLSRKFKDWAYGPVYSSLYDLSSLDTCGEEVSVLEILVYNSKIENRHEMLAVEPINELLRDKWRKFGAVSFYINVVSYLCAMVIFTLTAYYQPLEGTPPYPYRTTVDYLRLAGEVITLFTGVLFFFTSIKDLFTKKCPGVNSLFVDGSFQLLYFIYSVLVVVSAALYLAGIEAYLAVMVFALVLGWMNALYFTRGLKLTGTYSIMIQKILFKDLFRFLLVYLLFMIGYASALVTLLNPCTNMKVCDEDQSNCTVPTYPACRDSETFSAFLLDLFKLTIGMGDLEMLSSAKYPVVFILLLVTYIILTFVLLLNMLIALMGETVGQVSKESKHIWKLQWATTILDIERSFPVFLRKAFRSGEMVTVGKSSDGTPDRRWCFRVDEVNWSHWNQNLGIINEDPGKSEIYQYYGFSHTVGRLRRDRWSSVVPRVVELNKNSSADEVVVPLDNLGNPNCDGHQQGYAPKWRTDDAPL

PDB Structures

8J1B 8J1D 8J1F 8J1H

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

192;197;201;236..239;248;249..251;296..299;344;682

Disease

Location

Detected in liver; kidney; heart; brain cortex; cerebellum and brainstem (at protein level). Expressed in salivary glands (at protein level) Expressed in heart; lung; spleen; liver; kidney; brain; skeletal muscle and testis. In the central nervous system; expressed in the lamina terminalis (arched vascular organ and neurons of the subfornical organ); median preoptic area; ventral hippocampal commissure; and ependymal cells of the choroid plexus. In the central nervous system; expressed in the lamina terminalis (arched vascular organ and neurons of the subfornical organ); median preoptic area; ventral hippocampal commissure; and ependymal cells of the choroid plexus. In the central nervous system; expressed in the lamina terminalis (arched vascular organ and neurons of the subfornical organ); median preoptic area; ventral hippocampal commissure; and ependymal cells of the choroid plexus. In the cochlea; expressed in both inner and outer hair cells; and in marginal cells of the cochlear stria vascularis. Expressed in large neurons of the trigeminal ganglion. In the kidney cortex; strongly expressed by epithelial cells of tubules and much weaker in glomeruli. ...

DOI ID

10.1016/s0092-8674(00)00143-4; 10.1016/s0014-5793(00)02212-2; 10.1038/35036318; 10.1074/jbc.m302561200; 10.1101/gr.2596504; 10.1074/jbc.m204828200; 10.1074/jbc.m308212200; 10.1074/jbc.m211061200; 10.1073/pnas.0303329101; 10.1152/ajprenal.00245.2005; 10.1074/jbc.m600549200; 10.1074/jbc.m602452200; 10.1074/jbc.m706386200; 10.1083/jcb.200805124; 10.1074/jbc.m805357200; 10.1016/j.bbrc.2009.12.140; 10.1016/j.cell.2010.12.001; 10.1016/j.cell.2012.08.034; 10.1096/fj.13-243436; 10.1074/jbc.m110.103606

RefSeq

NP_071300.2; XP_006530495.2